From EcoReality

Contents 1 TITLE 2 AUTHORS 3 SOURCE 4 ABSTRACT 5 KEYWORDS 6 CAS REGISTRY NUMBERS 7 CODEN 8 ENTRY MONTH 9 YEAR OF PUBLICATION 10 SECONDARY SOURCE ID 11 DOCUMENT NUMBER 12 See also

TITLE

Effectiveness of Skin Absorption of Tincture of I in Blocking Radioiodine from the Human Thyroid Gland

AUTHORS

• Miller KL
• Coen PE
• White WJ
• Hurst WJ
• Achey BE
• Lang CM

SOURCE

Health Physics, Vol. 56, No. 6, pages 911-914, 13 references, 1989

ABSTRACT

Using 24 healthy adult male subjects, a study was carried out to determine the effectiveness of the topical application of tincture of iodine (7553562) (I) in blocking the thyroid uptake of orally administered iodine-131 (I131) in humans.

Each of the 24 subjects was administered I131 labeled sodium-iodide in orange juice. Of the 24, six subjects formed the comparison group and received no stable-I; six subjects received 4 milliliters (ml) of 2 percent tincture of-I on a single forearm over an area of approximately 200 by 50 millimeters (mm) 2 hours prior to I131 administration; six subjects received 8ml of 2 percent tincture of-I on the abdomen over an area of approximately 200 by 100mm 2 hours prior to I131 administration; and six subjects received an oral dose of 130 milligrams of potassium-iodide (7681110) (KI) 2 hours prior to I131 administration.

Serum-I concentrations peaked at approximately 2 hours after topical application of tincture of-I.

• Subjects receiving 8ml of tincture of-I on the abdomen had 26 hour post application (PA) serum-I levels ranging from 109 to 563 picograms per cubic milliliter (pg/mm3) and thyroid uptakes ranging from 0.20 to 6.7 percent.
• Subjects receiving 4ml of tincture of-I on the forearm had 26 hour PA serum-I levels ranging from 30.1 to 70.6pg/mm3 and thyroid uptakes ranging from 0.9 to 15.3 percent.
• Subjects receiving oral KI had 26 hour PA serum-I levels ranging from 215 to 1010pg/mm3 and thyroid uptakes ranging from 0 to 0.61 percent.
• Comparison subjects had 26 hour PA serum-I levels ranging from 7.24 to 16.5pg/mm3 and thyroid uptakes ranging from 6.5 to 14.8 percent.

Although there were large variations within each subject group in regard to serum-I levels and thyroid uptakes, the increase in serum-I concentration after topical-I application was effective in reducing the thyroid uptake of I131.

The authors conclude that in the absence of KI, most humans would benefit from topical application of tincture of-I, and that in some the effectiveness would equal that of oral KI.

The following table is not part of this paper's abstract.

Form	Dose	Serum-I lo	Serum-I hi	Uptake lo	Uptake hi
topical, abdomen	8	109	363	0.20%	6.70%
topical, forearm	4	30.1	70.6	0.90%	15.30%
potassium iodide	130	215	1010	0.00%	0.61%
control	0	7.24	16.5	6.50%	14.80%
units	millilitres for fluid, milligrams for tablet	picograms per millilitre	picograms per millilitre	portion of I-131 in thyroid	portion of I-131 in thyroid

KEYWORDS

• DCN-184012
• Prophylaxis
• Thyroid gland
• Halogens
• Potassium compounds
• Halogen compounds
• Skin absorption
• Radioactive isotopes
• Radionuclides

CAS REGISTRY NUMBERS

• 7553-56-2
• 7553-56-2
• 7681-11-0

CODEN

HLTPAO

ENTRY MONTH

199003

YEAR OF PUBLICATION

1989

SECONDARY SOURCE ID

NIOSH/00188573

DOCUMENT NUMBER

NIOSH/00188573

See also

• Radiation log of ionizing events recorded in the Fulford Valley of Salt Spring Island, British Columbia, Canada.
• Radiation fallout plan for minimizing the impact of radioactive fallout at EcoReality Co-op.